Health History | Moderna — Modified RNA From a First Street Lab
· 2010-9
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Health History | Moderna — Modified RNA From a First Street Lab
kevin
People treat Moderna as a Technology Square listing that always sold Spikevax from a Kendall Square campus.
The first book was a Flagship newco named for modified RNA.
In 2010 Noubar Afeyan of Flagship Pioneering sat with Robert Langer and Derrick Rossi over chemically modified messenger RNA that could reprogram adult cells. Afeyan wanted a medicine, not a stem-cell tool.
Flagship's VentureLabs group wrote Newco LS18, later Moderna Therapeutics. Timothy Springer and Kenneth Chien joined the founding group. Provisional patents went in that July and October.
Scientists moved into a First Street lab in Cambridge and spent months injecting modified constructs into rats. Stéphane Bancel joined the board in March 2011 and became chief executive that October.
The firm ran in stealth, raised about two billion dollars of venture money before any approved product, and listed in December 2018 in what was then the largest biotechnology IPO on record.
The mechanism is a Cambridge venture lab that treated messenger RNA as a programmable drug rather than a laboratory reagent, years before a pandemic made the platform public.
The pin is Kendall Square, where the First Street rooms sat, not the later Norwood plant.
Photo: Kendall Square, Cambridge, CC BY-SA, via Wikimedia Commons.
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